Article
Genetic determinants of co-accessible chromatin regions in activated T cells across humans.
Nature genetics - 1 Aug 2018
Gate Rachel E, Cheng Christine S, Aiden Aviva P, Siba Atsede, Tabaka Marcin, Lituiev Dmytro, Machol Ido, Gordon M Grace, Subramaniam Meena, Shamim Muhammad, Hougen Kendrick L, Wortman Ivo, Huang Su-Chen, Durand Neva C, Feng Ting, De Jager Philip L, Chang Howard Y, Aiden Erez Lieberman, Benoist Christophe, Beer Michael A, Ye Chun J, Regev Aviv
Abstract excerpt
Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease. One possible mechanism is that genetic variants affect the activity of one or more cis-regulatory elements leading to gene expression variation in specific cell types. To identify such cases, we analyzed ATAC-seq and RNA-seq profiles...
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