Article

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elements

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified hundreds of genetic signals associated with autoimmune disease. The majority of these signals are located in non-coding regions and likely impact cis -regulatory elements (cRE). Because cRE function is dynamic across cell types and states, profiling the epigenetic status of cRE across physiological processes is necessary to characterize the...

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Literature Corpus work: e84d8a07-0b68-51b9-864f-146d179544c5
DOI: 10.1101/2023.04.05.535731

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