Article

Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells

2021-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies have uncovered hundreds of autoimmune disease-associated loci; however, the causal genetic variant(s) within each locus are mostly unknown. Here, we perform high-throughput allele-specific reporter assays to prioritize disease-associated variants for five autoimmune diseases. By examining variants that both promote allele-specific reporter expression and are locat...

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Literature Corpus work: 0fe008db-7cdc-5ff1-ac14-477ad1f900ef
DOI: 10.1101/2021.05.30.445673

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