Article

Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in male 3xTg Alzheimer’s model mice

2024-09-30

Abstract excerpt

<title>Abstract</title> <p>Executive function depends on connectivity between the ventral hippocampus and medial prefrontal cortex (mPFC). How abnormalities in this pathway lead to cognitive dysfunction in Alzheimer’s disease (AD) have yet to be elucidated. Here, male 3xTg AD mice at 6-months displayed maladaptive decision-making in the rodent 4-Choice Gambling Task measure of executive function. Extracellular fi...

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Literature Corpus work: f191d199-6762-5e84-a934-9a6fa44ad358
DOI: 10.21203/rs.3.rs-4938291/v1

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