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Global dissection of the impact of Alzheimer’s disease on brain architecture and behavior: High resolution MRH resolves robust regional effects

2025-01-10

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) affects brain regions with remarkable heterogeneity, but the precise impact of this disease on hundreds of small cortical, subcortical, and brainstem regions remains poorly defined. Here, as a prelude to testing preclinical models to prevent AD, we systematically quantified effects of human AD mutations in APP and PSEN1 on 231 regions and comprehensively evaluated chan...

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Literature Corpus work
d887cfdb-c2ba-5c85-9582-add23bc95493
DOI
10.1101/2025.01.08.632011
Open publication

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Global dissection of the impact of Alzheimer’s disease on brain architecture and behavior: High resolution MRH resolves robust regional effectsDOI 10.1101/2025.01.08.632011
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