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Article

Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in mice

1 Apr 2021

Abstract excerpt

BACKGROUND: Major depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite both diseases having a robust genetic component, the common transcriptomic signature remains unknown. METHODS: We investigated the cognitive and emotional behavioural responses in 3- and 6-month-old APP/PSEN1-Tg mice, before β-amyloid plaques...

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PMID: 33795014
DOI: 10.1186/s13195-021-00810-x

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