Article

Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer’s disease

2023-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and leading cause of dementia, characterized by neuronal and synapse loss, amyloid-β and tau protein aggregates, and a multifactorial pathology involving neuroinflammation, vascular dysfunction, and disrupted metabolism. Additionally, there is growing evidence of imbalance between neuronal excitation and inhibition in the AD br...

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Literature Corpus work: d22c09cd-bc79-5c71-92a8-57b77bdf5835
DOI: 10.1101/2023.11.01.565165

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