Article

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimer’s Disease Risk in Humanized APOE Mice

2025-06-09

Abstract excerpt

Olfactory impairment is a hallmark of early Alzheimer’s disease (AD), but the underlying mechanisms connecting sensory decline to genetic and environmental risk factors remain unclear. Our integrative analysis combines ethologically relevant olfactory behavior assays, high-resolution diffusion MRI connectomics, and blood transcriptomics in a large cohort of humanized APOE mice stratified by APOE genotype (APOE2, A...

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Literature Corpus work: e281825a-d050-5293-9443-ee75a7e7c177
DOI: 10.1101/2025.06.06.658383

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