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Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In Mice

2023-12-06

Abstract excerpt

<h4>Background</h4> It is well established that glutamatergic neurotransmission plays an essential role in learning and memory. Previous studies indicate that glutamate dynamics shift with Alzheimer’s disease (AD) progression, contributing to negative cognitive outcomes. <h4>Objective</h4> In this study, we characterized hippocampal glutamatergic signaling with age and disease progression in a knock-in mouse mod...

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Literature Corpus work
483222f6-5852-5263-9fc9-7090ff896671
DOI
10.1101/2023.12.05.570100
Open publication

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Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In MiceDOI 10.1101/2023.12.05.570100
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