Back to search

Article

Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in male 3xTg Alzheimer’s model mice

2024-09-27

Abstract excerpt

Executive function depends on connectivity between the ventral hippocampus and medial prefrontal cortex (mPFC). How abnormalities in this pathway lead to cognitive dysfunction in Alzheimer’s disease (AD) have yet to be elucidated. Here, male 3xTg AD mice at 6-months displayed maladaptive decision-making in the rodent 4-Choice Gambling Task measure of executive function. Extracellular field recordings in the infral...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
12ac1964-27f3-5816-ac90-c4c5864ea067
DOI
10.1101/2024.09.26.615115
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in male 3xTg Alzheimer’s model miceDOI 10.1101/2024.09.26.615115
Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in male 3xTg Alzheimer’s model miceSemantic proximity
Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease miceSemantic proximity
Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 MiceSemantic proximity
Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse modelSemantic proximity
Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease ResearchSemantic proximity
Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s diseaseSemantic proximity
Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in miceSemantic proximity
Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimer’s Disease Risk in Humanized APOE MiceSemantic proximity
Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse modelSemantic proximity
Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics.Semantic proximity
Parity and APOEε4 genotype contribute distinct changes to functional connectivity across the middle-aged brainSemantic proximity
Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.