Article

Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse model

2021-05-26

Abstract excerpt

<title>Abstract</title> Background Alzheimer’s disease (AD) causes progressive age-related defects in memory and cognitive function, and has emerged as a major health and socio-economic concern in the US and worldwide. To develop effective therapeutic treatments for AD, we need to better understand the neural mechanisms by which AD causes memory loss and cognitive deficits. Methods Here we examine large scal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20ccbc14-8178-5f56-aafe-8bab9051dcd7
DOI: 10.21203/rs.3.rs-550358/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse modelDOI 10.21203/rs.3.rs-550358/v1Read

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse modelSemantic proximity Read

Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged App NL-G-F miceSemantic proximity Read

Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in male 3xTg Alzheimer’s model miceSemantic proximity Read

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentSemantic proximity Read

Circuit-specific selective vulnerability in the DMN persists in the face of widespread amyloid burdenSemantic proximity Read

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivoSemantic proximity Read

Disruption of the grid cell network in a mouse model of early Alzheimer’s diseaseSemantic proximity Read

40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Compartment-specific analysis reveals disrupted astrocytic calcium transients in Alzheimer's miceSemantic proximity Read

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.Semantic proximity Read

Intracellular Ca 2+ stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer’s diseaseSemantic proximity Read