Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease Research

doi:10.33549/physiolres.935464

Article

Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease Research

10 Mar 2025

Abstract excerpt

Alzheimer's disease (AD), a leading cause of dementia worldwide, is a multifactorial neurodegenerative disorder characterized by amyloid-beta plaques, tauopathy, neuronal loss, neuro-inflammation, brain atrophy, and cognitive deficits. AD manifests as familial early-onset (FAD) with specific gene mutations or sporadic late-onset (LOAD) caused by various genetic and environmental factors. Numerous transgenic...

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