Article

DOT1L limits RNAPII promoter-proximal pause release thus enabling Activation Induced Deaminase activity genome-wide

2023-06-21

Abstract excerpt

<title>Abstract</title> <p> Activation induced deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutation of the antibody genes but also mutates “off-target” genes, with oncogenic consequences. Understanding the mechanisms that render such loci susceptible to AID is therefore necessary. We identify the H3K79 histone methyltransferase DOT1L as a nuclear AID-proximal factor required for C...

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Literature Corpus work: f034ba3d-723a-5f48-be18-92d0634062d9
DOI: 10.21203/rs.3.rs-3055610/v1

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