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Article

Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

2024-09-26

Abstract excerpt

<h4>Summary</h4> Somatic hypermutation (SHM) and class switch recombination (CSR) diversify immunoglobulin (Ig) genes and are initiated by the activation induced deaminase (AID), a single-stranded DNA cytidine deaminase that is thought to engage its substrate in the context of RNA polymerase II (RNAPII) transcription. Through a loss of function genetic screen, we identified numerous potential factors involved in...

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Literature Corpus work
794dfc27-bef3-5c14-b3bd-0520eaad29d0
DOI
10.1101/2024.09.24.614732
Open publication

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Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombinationDOI 10.1101/2024.09.24.614732
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