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Article

Epigenetic targeting of activation-induced cytidine deaminase

1 Jan 2014

Abstract excerpt

Activation-induced cytidine deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igκ, and Igλ). At a lower frequency, AID also causes collateral DNA damage at non-Ig loci, including genes that are rearranged or mutated in B-cell lymphoma. Precisely how AID is recruited to these off-target sites is not entirely...

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PMID: 25512519
DOI: 10.1073/pnas.1420575111

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