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Article

DOT1L Complex Regulates Transcriptional Initiation in Human Cells

2020-12-07

Abstract excerpt

<h4>SUMMARY</h4> DOT1L, the only H3K79 methyltransferase in human cells and a homolog of the yeast Dot1, normally forms a complex with AF10, AF17 and ENL/AF9, is dysregulated in most of the cases of mixed lineage leukemia (MLL) and is believed to regulate transcriptional elongation without much evidence. Here we show that the depletion of DOT1L reduced the global occupancy without affecting the traveling ratio or...

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Identifiers and source

Literature Corpus work
ce9fdf63-6eb7-5ba9-ba37-0a9f7507c061
DOI
10.1101/2020.12.07.414722
Open publication

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DOT1L Complex Regulates Transcriptional Initiation in Human CellsDOI 10.1101/2020.12.07.414722
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