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Article

A licensing step links AID to transcription elongation for mutagenesis in B cells.

Nature communications - 28 Mar 2018

Methot Stephen P, Litzler Ludivine C, Subramani Poorani Ganesh, Eranki Anil K, Fifield Heather, Patenaude Anne-Marie, Gilmore Julian C, Santiago Gabriel E, Bagci Halil, Côté Jean-François, Larijani Mani, Verdun Ramiro E, Di Noia Javier M

Abstract excerpt

Activation-induced deaminase (AID) mutates the immunoglobulin (Ig) genes to initiate somatic hypermutation (SHM) and class switch recombination (CSR) in B cells, thus underpinning antibody responses. AID mutates a few hundred other loci, but most AID-occupied genes are spared. The mechanisms underlying productive deamination versus non-productive AID targeting are unclear. Here we show that three clustered...

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Source

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Identifiers

PMID: 29593215
DOI: 10.1038/s41467-018-03387-6
PMCID: PMC5871760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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