Article

Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency

2022-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Pluripotent embryonic stem cells (ESCs) have a transcriptionally permissive chromatin environment enriched for gene activation-associated histone modifications as compared to somatic cells. A striking exception is DOT1L-mediated H3K79 methylation that is considered a positive regulator of transcription. Here we find that ESCs maintain low H3K79 methylation to facilitate RNA polymerase II (RNAPII...

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Literature Corpus work: d527ede9-ca82-5bb7-bdb9-6c9d19288b55
DOI: 10.1101/2022.09.26.509534

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Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotencyDOI 10.1101/2022.09.26.509534Read

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