Article

Three-Dimensional Epigenome Roadmap of Human B-cell Differentiation Uncovers Mechanisms of Humoral Immunity and Oncogenesis

2025-12-24

Abstract excerpt

Human B-cell differentiation underlies humoral immunity, and its disruption leads to cancer, autoimmunity, and immunodeficiencies. However, the enhancer-based regulatory mechanisms governing this process remain poorly understood. To address this gap, we generated the first three-dimensional epigenomic roadmap of human B-cell differentiation in vivo . By profiling nine differentiation stages, we linked nearly half...

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Literature Corpus work: 331bd0f7-72c8-52be-9343-ac83847b8032
DOI: 10.64898/2025.12.22.695871

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