Article

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

2019-08-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Ribosomal DNA (rDNA) transcription by the RNA polymerase I (Pol I) is a rate-limited step for ribosome synthesis, which is critical for cell growth, cell differentiation, and tumorigenesis. Meanwhile rDNA transcription is modulated by DNA methylation and histone epigenetic modification. Though with great progress in epigenetic research recently, it still remains much uncerta...

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Literature Corpus work: a30e8f48-6f68-5040-9b5d-d016a530011e
DOI: 10.1101/745307

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