Article

Multiple Myeloma associated DIS3 mutations drive AID-dependent IGH Translocations

2023-07-27

Abstract excerpt

<h4>Summary</h4> Role of dominant DIS3 mutations in multiple myeloma (MM) remains elusive. These mutations decrease the exoribonucleolytic activity of DIS3, a key nuclear RNA-degrading enzyme. Utilizing knock-in mice with clinical Dis3 G766R variant, we demonstrate an increased frequency of aberrant chromosomal translocations in B-cells, leading to plasmacytoma, an early-stage MM model. DIS3-dependent translocati...

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Literature Corpus work: ee72cdb2-5510-5ba5-adfd-327de182a153
DOI: 10.1101/2023.07.27.550610

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