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Article

The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.

Cell research - 1 Oct 2018

Chen Juan, Cai Zhaokui, Bai Meizhu, Yu Xiaohua, Zhang Chao, Cao Changchang, Hu Xihao, Wang Lei, Su Ruibao, Wang Di, Wang Lei, Yao Yingpeng, Ye Rong, Hou Baidong, Yu Yang, Yu Shuyang, Li Jinsong, Xue Yuanchao

Abstract excerpt

Activation-induced cytidine deaminase (AID) mediates class switching by binding to a small fraction of single-stranded DNA (ssDNA) to diversify the antibody repertoire. The precise mechanism for highly selective AID targeting in the genome has remained elusive. Here, we report an RNA-binding protein, ROD1 (also known as PTBP3), that is both required and sufficient to define AID-binding sites genome-wide in...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Identifiers

PMID: 30143796
DOI: 10.1038/s41422-018-0076-9
PMCID: PMC6170407

Genes

PTBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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