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DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity

2020-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Histone 3 Lysine 79 methylation (H3K79me) is enriched on gene bodies proportional to gene expression levels, and serves as a strong barrier for reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). DOT1L is the sole histone methyltransferase that deposits all three orders - mono, di, and tri methylation – at H3K79. Here we leverage genetic and chemical approaches to parse the...

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Literature Corpus work
82200185-431b-54bc-ba07-0b9bf6d9c940
DOI
10.1101/2020.12.17.423347
Open publication

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DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identityDOI 10.1101/2020.12.17.423347
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