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Increased tau expression in the <i>APOE4</i> blood-brain barrier model is associated with reduced anti-tau therapeutic antibody delivery <i>in vitro</i>

2023-10-25

Abstract excerpt

Tau protein is a critical driver of neurodegeneration and an important drug target in Alzheimer’s disease (AD). Tau-specific immunotherapy has emerged as a promising treatment strategy for AD, however the therapeutic efficacy of anti-tau antibodies may be limited by their insufficient delivery across the blood-brain barrier (BBB). The apolipoprotein E4 allele ( APOE4 ) is the strongest genetic risk factor for spo...

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Literature Corpus work
efbe6227-c762-5c5b-a5f3-5ae463b64b1c
DOI
10.1101/2023.10.24.563706
Open publication

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Increased tau expression in the <i>APOE4</i> blood-brain barrier model is associated with reduced anti-tau therapeutic antibody delivery <i>in vitro</i>DOI 10.1101/2023.10.24.563706
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