Article

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer’s disease mouse model

2025-12-13

Abstract excerpt

<h4>ABSTRACT</h4> Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). Within the central nervous system (CNS), APOE is produced by a variety of cell types, with differential roles in AD pathogenesis. Studies have shown that APOE4 produced by neurons plays a central role in promoting the development of major AD pathologies, including p-tau accumulation, neuroinfl...

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Literature Corpus work: 9e86babf-36f8-5d41-86c3-2687a4338445
DOI: 10.64898/2025.12.10.693468

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