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ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells

2024-09-03

Abstract excerpt

<h4>Summary</h4> Transferrin receptor in brain endothelial cells can deliver therapeutic antibodies to the brain via transcytosis across the blood-brain barrier. Whether receptor transport remains intact in Alzheimer’s disease is still a major open question. Here, we investigated whether apolipoprotein E4 (ApoE4), the major genetic risk factor for Alzheimer’s disease, altered intracellular transport in human brai...

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Literature Corpus work
3ca0d809-65ef-5709-86ce-b3ff81a63e6f
DOI
10.1101/2024.09.03.610802
Open publication

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ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cellsDOI 10.1101/2024.09.03.610802
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