Article

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

2025-09-17

Abstract excerpt

<h4>Background</h4> Alternative splicing of the MAPT gene produces distinct tau isoforms in the central and peripheral nervous systems (CNS and PNS), yet their respective biological and pathological roles remain poorly understood. Recent studies suggest that CNS-tau may play a key role in amyloid-β associated neurodegeneration in Alzheimer’s disease (AD), but the absence of isoform-specific tools has limited both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa95837a-2d08-5c4f-b18a-03b530028939
DOI: 10.1101/2025.09.14.676119

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across TauopathiesDOI 10.1101/2025.09.14.676119Read

Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistrySemantic proximity Read

[Tauopathies : From molecule to therapy].Semantic proximity Read

Tauopathies: new perspectives and challengesSemantic proximity Read

Validation of Tau Antibodies for Use in Western Blotting and ImmunohistochemistrySemantic proximity Read

The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromesSemantic proximity Read

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.Semantic proximity Read

Tau; One Protein, So Many DiseasesSemantic proximity Read

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s diseaseSemantic proximity Read

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's DiseaseSemantic proximity Read

Progress regarding the context-of-use of tau as biomarker of Alzheimer’s disease and other neurodegenerative diseasesSemantic proximity Read

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.Semantic proximity Read

Alzheimer's disease: phenotypic approaches using disease models and the targeting of tau protein.Semantic proximity Read