Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

Abstract excerpt

Patient-specific, human-based cellular models integrating a biomimetic blood-brain barrier (BBB), immune, and myelinated neuron components are critically needed to enable accelerated, translationally relevant discovery of neurological disease mechanisms and interventions. By engineering a novel brain-mimicking 3D hydrogel and co-culturing all six major brain cell types derived from patient iPSCs, we have construct...

Topics

Open a Topic to create a Post that cites this publication.

• 3D Printing in Biomedical Research
• Glioma Diagnosis and Treatment
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

714837b7-0a47-5a83-9b9d-1cb860560703

DOI

10.1101/2023.08.15.553453