Article

Transferrin-Functionalized Liposomes Enhance Mapt-Aso Transport Across a 3D Blood-Brain Barrier Microvascular Network Model

2025-10-17

Abstract excerpt

Tau pathology is a defining hallmark of Alzheimer’s disease (AD), closely associated with cognitive decline. Antisense oligonucleotides targeting the tau-encoding gene MAPT (MAPT-ASO) have shown promise in clinical trials, but their therapeutic potential is limited by poor delivery across the blood–brain barrier (BBB). In this study, we developed transferrin (TF)-functionalized liposomes encapsulating MAPT-ASOs an...

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Literature Corpus work: 2ddfa8ad-cf0c-5ccc-911b-54a77572bb0b
DOI: 10.20944/preprints202510.1363.v1

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Transferrin-Functionalized Liposomes Enhance Mapt-Aso Transport Across a 3D Blood-Brain Barrier Microvascular Network ModelDOI 10.20944/preprints202510.1363.v1Read

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