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<i>APOE-</i> ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer’s disease

2025-01-27

Abstract excerpt

Blood-brain barrier (BBB) dysfunction is a key feature of Alzheimer’s disease (AD), particularly in individuals carrying the APOE-ε4 allele. This dysfunction worsens neuroinflammation and hinders the removal of toxic proteins, such as amyloid-beta (Aβ42), from the brain. In post-mortem brain tissues and in animal models, we previously reported that fibronectin accumulates at the BBB predominantly in APOE-ε4 carr...

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Literature Corpus work
c2be273d-a6a0-5f05-bf2d-5645d07a031f
DOI
10.1101/2025.01.24.634732
Open publication

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<i>APOE-</i> ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer’s diseaseDOI 10.1101/2025.01.24.634732
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