Article

APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition

2025-09-09

Abstract excerpt

Cerebrovascular disease is a major but poorly understood feature of Alzheimer’s disease (AD). The strongest genetic AD risk factor, APOE4, is associated with cerebrovascular degeneration, including vascular amyloid deposition and fibrosis. To uncover how APOE4 promotes cerebrovascular pathology, we assembled a single-cell transcriptomic atlas of human brain vasculature. In APOE4 carriers, pericyte abundance was si...

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Literature Corpus work: 54919607-111f-534f-8735-2c42e38786d0
DOI: 10.1101/2025.09.04.674192

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