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iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta

11 Oct 2024

Abstract excerpt

BACKGROUND: Three common isoforms of the apolipoprotein E (APOE) gene - APOE2, APOE3, and APOE4 - hold varying significance in Alzheimer's Disease (AD) risk. The APOE4 allele is the strongest known genetic risk factor for late-onset Alzheimer's Disease (AD), and its expression has been shown to correlate with increased central nervous system (CNS) amyloid deposition and accelerated neurodegeneration. Conversely,...

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Alzheimer's disease research and treatments
Barrier Structure and Function Studies
Dementia and Cognitive Impairment Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39394110
DOI: 10.1186/s12987-024-00580-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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