Article
Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery.
Stem cell reports - 12 May 2020
Oikari Lotta E, Pandit Rucha, Stewart Romal, Cuní-López Carla, Quek Hazel, Sutharsan Ratneswary, Rantanen Laura M, Oksanen Minna, Lehtonen Sarka, de Boer Carmela Maria, Polo Jose M, Götz Jürgen, Koistinaho Jari, White Anthony R
Abstract excerpt
The blood-brain barrier (BBB) presents a barrier for circulating factors, but simultaneously challenges drug delivery. How the BBB is altered in Alzheimer disease (AD) is not fully understood. To facilitate this analysis, we derived brain endothelial cells (iBECs) from human induced pluripotent stem cells (hiPSCs) of several patients carrying the familial AD PSEN1 mutation. We demonstrate that, compared with...
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