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Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer’s disease

2025-05-26

Abstract excerpt

<title>Abstract</title> <p>Brain-derived extracellular vesicles (BDEVs) carry tau filaments and promote tau transmission in Alzheimer’s disease (AD). However, how APOE ε4 allele, a key genetic risk factor for AD, may change BDEV molecular structures thereby facilitate disease progression is poorly understood. Here we report comprehensive analyses of BDEVs isolated from human E3/3 and E4/4 AD brains with a biologi...

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Literature Corpus work
b3186642-a3b9-562d-9fa3-5e414708a95e
DOI
10.21203/rs.3.rs-6508552/v1
Open publication

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Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer’s diseaseDOI 10.21203/rs.3.rs-6508552/v1
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