Article

The dynamic role of HLA proteins on compositional alterations of T-cell repertoires in inflammatory bowel disease

2025-10-27

Abstract excerpt

<h4>Background</h4> Inflammatory bowel disease (IBD), which is characterised by genetic predispositions and dysregulated immune responses, is rapidly emerging as a global health challenge. Genetic variations in the human leukocyte antigen (HLA) region are strongly associated with IBD; nonetheless, the functional consequences of this variation on the composition of T-cell receptors remain poorly understood. <h4>Me...

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Literature Corpus work: ef16ff5d-d8c1-5aa2-bbd3-852ca0bd9a9d
DOI: 10.1101/2025.10.27.683825

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