Article
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Nature genetics - 1 Feb 2015
Goyette Philippe, Boucher Gabrielle, Mallon Dermot, Ellinghaus Eva, Jostins Luke, Huang Hailiang, Ripke Stephan, Gusareva Elena S, Annese Vito, Hauser Stephen L, Oksenberg Jorge R, Thomsen Ingo, Leslie Stephen, Daly Mark J, Van Steen Kristel, Duerr Richard H, Barrett Jeffrey C, McGovern Dermot P B, Schumm L Philip, Traherne James A, Carrington Mary N, Kosmoliaptsis Vasilis, Karlsen Tom H, Franke Andre, Rioux John D
Abstract excerpt
Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that...
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