Article
Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations.
Human molecular genetics - 27 Apr 2021
Degenhardt Frauke, Mayr Gabriele, Wendorff Mareike, Boucher Gabrielle, Ellinghaus Eva, Ellinghaus David, ElAbd Hesham, Rosati Elisa, Hübenthal Matthias, Juzenas Simonas, Abedian Shifteh, Vahedi Homayon, Thelma B K, Yang Suk-Kyun, Ye Byong Duk, Cheon Jae Hee, Datta Lisa Wu, Daryani Naser Ebrahim, Ellul Pierre, Esaki Motohiro, Fuyuno Yuta, McGovern Dermot P B, Haritunians Talin, Hong Myhunghee, Juyal Garima, Jung Eun Suk, Kubo Michiaki, Kugathasan Subra, Lenz Tobias L, Leslie Stephen, Malekzadeh Reza, Midha Vandana, Motyer Allan, Ng Siew C, Okou David T, Raychaudhuri Soumya, Schembri John, Schreiber Stefan, Song Kyuyoung, Sood Ajit, Takahashi Atsushi, Torres Esther A, Umeno Junji, Alizadeh Behrooz Z, Weersma Rinse K, Wong Sunny H, Yamazaki Keiko, Karlsen Tom H, Rioux John D, Brant Steven R, Franke Andre
Abstract excerpt
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifically DRB1*01:03 as a determining factor for ulcerative colitis (UC). However, for most of the association signal such as delineation could not be made because of tight structures...
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