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Antigen-driven expansion of public clonal T-cell populations in inflammatory bowel diseases

13 Mar 2025

Abstract excerpt

BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are known to involve shifts in the T-cell repertoires of affected individuals, including clonal expansion of abundant T-cell populations in CD mucosal tissue. There are also differential human leukocyte antigen (HLA) risk and protective alleles between CD and UC, implying CD- and UC-specific...

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PMID: 40121186
DOI: 10.1093/ecco-jcc/jjaf048

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