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Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease

13 Sept 2019

Abstract excerpt

BACKGROUND: The human leucocyte antigen (HLA) complex, located at chromosome 6p21.3 is a highly polymorphic region containing the classical class I and II HLA genes. The region is highly associated with inflammatory bowel disease (IBD), largely through genome-wide association studies (GWAS). AIMS: To review the role of HLA in immune function, summarise data on risk/protective HLA genotypes for IBD, discuss the...

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PMID: 31518029
DOI: 10.1111/apt.15485

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