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Article

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors.

Nature genetics - 1 Apr 2022

Ishigaki Kazuyoshi, Lagattuta Kaitlyn A, Luo Yang, James Eddie A, Buckner Jane H, Raychaudhuri Soumya

Abstract excerpt

Polymorphisms in the human leukocyte antigen (HLA) genes strongly influence autoimmune disease risk. HLA risk alleles may influence thymic selection to increase the frequency of T cell receptors (TCRs) reactive to autoantigens (central hypothesis). However, research in human autoimmunity has provided little evidence supporting the central hypothesis. Here we investigated the influence of HLA alleles on TCR...

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Source

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Identifiers

PMID: 35332318
DOI: 10.1038/s41588-022-01032-z
PMCID: PMC9010379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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