Article

<i>HLA</i>autoimmune risk alleles restrict the hypervariable region of T cell receptors

2020-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Polymorphisms in the human leukocyte antigen ( HLA ) genes within the major histocompatibility complex ( MHC ) locus strongly influence autoimmune disease risk 1–5 . Two non-exclusive hypotheses exist about the pathogenic role of HLA alleles; i) the central hypothesis, where HLA risk alleles influence thymic selection so that the probability of T cell receptors (TCRs) reactive to pathogenic antig...

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Literature Corpus work: 4ea03e2c-abea-55b0-98b6-b97ff29a7819
DOI: 10.1101/2020.11.08.20227983

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