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Article

Interpretable GWAS by linking clinical phenotypes to quantifiable immune repertoire components.

Communications biology - 20 Oct 2024

Tan Yuhao, Wang Lida, Zhang Hongyi, Pan Mingyao, Liu Dajiang J, Zhan Xiaowei, Li Bo

Abstract excerpt

Bridging the gap between genotype and phenotype in GWAS studies is challenging. A multitude of genetic variants have been associated with immune-related diseases, including cancer, yet the interpretability of most variants remains low. Here, we investigate the quantitative components in the T cell receptor (TCR) repertoire, the frequency of clusters of TCR sequences predicted to have common antigen specificity,...

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Identifiers

PMID: 39428403
DOI: 10.1038/s42003-024-07010-x
PMCID: PMC11491462

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