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Article

Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis.

JCI insight - 10 Aug 2026

Chan Joshua E, Mohsin Azam, Krijgsman Jens, Lindelauf Ciska, Mu Qinghui, Cavalla Brianna, Ji Xuhuai, Streett Sarah E, van Unen Vincent, Davis Mark M

Abstract excerpt

Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is marked by chronic intestinal inflammation and dysregulated immunity. Although UC and CD affect different areas of the gastrointestinal tract, both diseases share aberrant CD4+ memory T cell responses, with HLA-DRB1 as a major genetic risk factor. HLA-DRB1 encodes MHC class II molecules that influence the CD4+ T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Colitis, Ulcerative

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Share to HLA-DRB1 Chains

Share to Receptors, Antigen, T-Cell

Source

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Identifiers

PMID: 42262895
DOI: 10.1172/jci.insight.195354
PMCID: PMC13463618

Genes

CD4
GZMB
PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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