Article

Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain

2025-05-07

Abstract excerpt

Abnormal epigenetic modifications, including altered chromatin accessibility, have been implicated in the development and progression of Alzheimer's disease (AD). In this study, we applied spatially resolved chromatin accessibility profiling by performing spatial assay for transposase-accessible chromatin using sequencing (ATAC-seq) to analyze brain tissues from 5xFAD AD model and C57BL/6J control mice. Our analys...

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Literature Corpus work: ee0e61db-04b2-5f61-a350-2fabbd504a68
DOI: 10.1101/2025.05.01.651759

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