Article

Context-dependent regulatory networks connect Alzheimer’s disease genetics to microglial inflammatory responses

2026-08-26

Abstract excerpt

Inflammation is central to Alzheimer’s disease (AD) pathogenesis. Microglia, the resident innate immune cells of the brain, exhibit diverse inflammatory states and are enriched for AD-associated genetic variants within active cis -regulatory elements (CREs). However, the interplay among genetic variants, transcription factor (TF)–CRE– gene programs, and microglial responses across inflammatory and disease context...

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Literature Corpus work: ca669773-6d7c-5cb6-83f6-cf36680150b0
DOI: 10.64898/2026.08.24.746572

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