Article

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tangles

2021-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Multiple mouse models have been generated that strive to recapitulate human Alzheimer’s disease (AD) pathological features to investigate disease mechanisms and potential treatments. The 3xTg-AD mouse presents the two major hallmarks of AD, which are plaques and tangles that increase during aging. While behavioral changes and the accumulation of plaques and tangles have been well described in th...

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Literature Corpus work: 1248e221-83ba-5236-9de9-c204789b0253
DOI: 10.1101/2021.09.29.462436

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Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tanglesDOI 10.1101/2021.09.29.462436Read

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