Article

Multidimensional Transcriptomics Reveals the Pivotal Role of Neuroinflammation in Alzheimer's Disease

2026-04-21

Abstract excerpt

Alzheimer’s Disease (AD), the most prevalent form of dementia, is pathologically defined by extracellular beta-amyloid (Aβ) plaques and intraneuronal neurofibrillary tangles (NFTs), accompanied by chronic neuroinflammation. Recent advances in single-cell RNA sequencing (scRNA-seq/snRNA-seq) and spatial transcriptomics have provided unprecedented resolution for dissecting the cellular and molecular landscape of neu...

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Literature Corpus work: a6ee9442-8ae6-5d2d-be5e-7b3bb2584c60
DOI: 10.20944/preprints202604.1477.v1

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