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Article

Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model

23 Mar 2020

Abstract excerpt

BACKGROUND: The pathological hallmarks of Alzheimer's disease (AD) involve alterations in the expression of numerous genes associated with transcriptional levels, which are determined by chromatin accessibility. Here, the landscape of chromatin accessibility was studied to understand the outline of the transcription and expression of AD-associated metabolism genes in an AD mouse model. METHODS: The assay for...

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PMID: 32293531
DOI: 10.1186/s13195-020-00598-2

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