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Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics

6 Jan 2023

Abstract excerpt

We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymorphisms (SNPs) associated with late onset AD (LOAD) show a strong tendency to reside in microglia-specific gene regulatory elements. Despite this significant...

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PMID: 36683855
DOI: 10.3389/fnmol.2022.948456

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