Article

The three-dimensional landscape of chromatin accessibility in Alzheimer’s disease

2021-01-12

Abstract excerpt

Much is still unknown about the neurobiology of Alzheimer’s disease (AD). To better understand AD, we generated 636 ATAC-seq libraries from cases and controls to construct detailed genomewide chromatin accessibility maps of neurons and non-neurons from two AD-affected brain regions, the entorhinal cortex and superior temporal gyrus. By analyzing a total of 19.6 billion read pairs, we expanded the known repertoire...

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Literature Corpus work: 2a75eaad-a45f-5e85-9823-7c8adacb3ed7
DOI: 10.1101/2021.01.11.426303

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